Understanding Dosing & Concentrations

Understanding Dosing & Concentrations

One of the most confusing aspects of compounded GLP-1 medications is understanding how dosing works. This guide breaks it down in plain language.

Units of Measurement

GLP-1 medications are typically measured in milligrams (mg). A typical dose might range from 0.25mg to 2.4mg for semaglutide, or 2.5mg to 15mg for tirzepatide.

Concentration Explained

Compounded GLP-1s are sold as a liquid solution. The concentration tells you how much active ingredient is in each milliliter (mL) of liquid.

For example:

• A concentration of 2.5 mg/mL means each mL of liquid contains 2.5mg of semaglutide
• To get a 0.5mg dose, you would inject 0.2 mL of this solution

Why Concentration Matters

Different providers may offer different concentrations. A higher concentration means:

• Less liquid to inject per dose
• Potentially more doses per vial
• Different injection volumes

Always verify the concentration with your provider and never assume two products are interchangeable.

The Titration Schedule

Most providers follow a titration (dose escalation) schedule:

1. Week 1-4: Start at a low dose to assess tolerance and minimize side effects
2. Week 5-8: Increase dose if tolerated well
3. Week 9+: Continue titrating to the target maintenance dose

This gradual increase helps your body adjust and reduces side effects like nausea.

Reading the Label

When you receive your medication, the label should clearly state:

• The active ingredient (semaglutide or tirzepatide)
• The concentration (mg/mL)
• The volume in the vial
• Storage instructions
• Expiration date

Always follow your prescribing provider's instructions. Never adjust your dose without consulting them.