What Are GLP-1 Medications?
A clear introduction to GLP-1 receptor agonists — how they work, what they treat, and why they're used for weight loss.
What Are GLP-1 Medications?
GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications originally developed to treat type 2 diabetes. In recent years, they have gained significant attention for their effectiveness in supporting weight loss.
How Do They Work?
GLP-1 receptor agonists mimic a naturally occurring hormone that:
- Signals fullness to your brain
- Slows gastric emptying (how quickly food leaves your stomach)
- Reduces appetite and food cravings
Common GLP-1 Medications
The two most common active ingredients in compounded GLP-1 products are:
- Semaglutide — the active ingredient in Ozempic and Wegovy
- Tirzepatide — the active ingredient in Mounjaro and Zepbound
Compounded vs. Brand Name
Brand-name GLP-1 medications (Wegovy, Zepbound, Ozempic) are manufactured by pharmaceutical companies and FDA-approved. Compounded versions are prepared by compounding pharmacies and are not FDA-approved, though they use the same active ingredients.
Important: Compounded medications are not reviewed by the FDA for safety, effectiveness, or quality the way brand-name drugs are. Always discuss the risks and benefits with your healthcare provider.
Why Are People Using Compounded GLP-1s?
Many people turn to compounded GLP-1 medications because:
- Brand-name medications are often not covered by insurance for weight loss
- Out-of-pocket costs for Wegovy and Zepbound can exceed $1,000/month
- Compounded versions are typically significantly less expensive
- Online telehealth providers have made access easier
Key Takeaway
GLP-1 medications can be an effective tool for weight loss, but they are serious medications with potential side effects. Understanding how they work is the first step in making an informed decision with your healthcare provider.
Medical Disclaimer
This content is for educational purposes only and is not medical advice. GLP-1 Primer does not recommend or endorse any specific medication, provider, or treatment. Always consult a licensed healthcare professional before making decisions about your health.
